Cancer Through A Stem Cell Lens

Part of the Oncology Grand Rounds Series - David Scadden, MD, Department of Stem Cell and Regenerative Biology at Harvard University, explains how proton shifting alters metabolism sufficiently to enable increased cell proliferation. He also recognizes MCT4 as driving pHi increases in AML and how multiple AML genotypes epigenetically enforce MCT4 over expression. Dr. Scadden also discusses how considering cancer in terms of corrupted cell programs may provide therapeutic opportunities.