Part of the Surgical Grand Rounds Series - Drs. Richard Ambinder, Samantha Vogt, and Rena Xian discuss how to approach diagnostic challenges in HIV Hodgkin Lymphoma, and describe opportunities for plasma DNA diagnostics. Dr. Ambinder also explains the association between EBV and Hodgkin Lymphoma. Dr. Vogt reviews the HIV epidemic in South Africa and how it relates to the new Hodgkin Lymphoma diagnosis. Dr. Xian presents about plasma with circulating nucleic acids and proteins.